PIK3CA Mutation ( Lung cancer, colorectal cancer, gastric cancer, breast cancer)
Phosphatidylinositol kinase-3（phosphoinositide-3-kinase，PI3K） Plays an important role in the development of non-small cell lung cancer, which canAKT Phosphorylation activates downstream channels, promoting the survival and expansion of tumor cells. PI3K Channels are associated with many signals that regulate important cellular functions, such as cell growth, proliferation, differentiation, motility, and survival. InP110-α Amino acids in proteinsR38、R93、K111、E453、E545、Q546、M1043 AndH1047 Found onPIK3CA Misunderstanding mutation, this mutation is carcinogenic. Research shows thatPIK3CA Gene mutation is associated with the generation and development of colorectal cancer, gastric cancer, breast cancer, lung cancer and other malignant tumors. About10% Squamous cell carcinoma of the lung and7% All lung adenocarcinomas have appearedPIK3CA The mutation. In squamous cell carcinoma of the lungPIK3CA The frequency of amplification and mutation is much higher in lung adenocarcinoma, and34-42% This gene can be amplified in lung squamous cell carcinoma.
Targeted therapeutic drugs：
FDA Approved for use in other types of tumorsmTOR Inhibitor everolimus(Everolimus) Hepitesirolimus(Temsirolimus). Another drug under researchIpatasertib，Ipatasertib It is a targeted productP13K/AKT Oral specific inhibitors of signaling pathwaysPI3K/AKT The signaling pathway is believed to be one of the mechanisms by which tumor cells develop resistance to immune checkpoint inhibitors, thus inhibitingPI3K/AKT The signaling pathway may reverse the resistance of tumor cells to immunotherapy.
