Gene-guided therapy - Target Therapy

基因類別: PD-L1 基因

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My wife is 54 years old and in good spirits. She underwent a second stage rectal tumor resection in June 2019 without follow-up treatment. After the surgery, her CEA index was 3.2; In June 2020, the CEA index rose to 10, and it was discovered that colorectal cancer had metastasized to the liver. The first course of treatment (injection of Oxaliplatin plus oral Xeloda for two weeks) began on June 26, and then the patient was transferred to a public hospital for targeted therapy and chemotherapy. The patient completed the first targeted therapy with Cetuximab and the second chemotherapy with Oxaliplatin (Eloxatin), Fluorouracil (5FU), and Folinic Acid on 15/7. I should be readmitted for further treatment in two weeks. On July 27th, a blood test was taken. Due to low platelet count and high liver enzymes, another blood test was needed on August 3rd, one week later, to determine whether I could continue chemotherapy. Unfortunately, on August 4th, I saw a doctor who said that the blood test results showed a platelet index of 0.8 and liver enzymes were three times normal. Therefore, I have not been able to start the second targeted therapy and the third chemotherapy. It depends on the blood test results on August 10th to know whether I can start the next course of treatment. That is, the third chemotherapy has been delayed for three weeks. The current question is that my wife's CEA index of 3.3 has decreased compared to before chemotherapy. However, if the blood test results continue to be unsatisfactory and treatment is delayed, will it have an impact on her condition and drug resistance? Also, may I ask how to increase platelets and decrease liver enzyme index during this period? Teach with effort!